by Seng-Lai Tan (Editor)
Provides readers with a clear understanding
of the value and challenges of using common and emerging preclinical
models in cancer immunotherapy research and development.
Animal
models are essential tools for studying a range of issues in
preclinical and clinical research on therapies targeting cancerous
tumors. As clinical trials of advances in cancer immunotherapy are
predicted to outpace preclinical research in the near future, there
remains an urgent need to develop better animal models for preclinical
evaluation of novel modulators. Animal Models for the Development of Cancer Immunotherapy
provides a detailed overview of different preclinical model systems for
development of novel cancer immunotherapies while highlighting how key
aspects of individual models translate into clinical findings.
Covering
the introduction, development, and therapeutic applications of animal
models for cancer immunotherapy, this comprehensive volume helps
pharmacologists identify suitable animal models, design pharmacological
or translational studies, and advance their mechanistic understanding of
therapeutic agents, and increase the possibility of success for novel
immunotherapies in clinical settings. Chapters written by prominent
leaders in the field address specific models that evaluate
immuno-oncology drugs are supported by in-depth case studies and
extensive references throughout.
- Emphasizes
the importance of modeling tumor metastasis in preclinical models for
efficient translation of findings into the clinic
- Explores recently discovered mechanisms of resistance and their preclinical modeling
- Highlights the unique characteristics and features of autologous and allogeneic approaches for humanization of mouse models
- Reviews
development of bone marrow-liver-thymus (BLT) immune humanized mice and
emerging alternative models such as genetically engineered mouse models
(GEMM)
- Discusses alternative animal models for cancer research such as severe combined immunodeficiency (SCID) pigs
Animal Models for the Development of Cancer Immunotherapy
is an essential resource for scientists and researchers in the
pharmaceutical and biotechnology industries, medicinal chemists and
biochemists, cell and molecular biologists, pharmacologists,
immunologists, and clinicians.
English | 2022 | PDF | 6 MB | 308 Pages
ISBNs: 111953528X, 978-1119535287, 9781119535287, B0B94VG5Z7
