2nd Edition
by David E. Thurston, Ilona Pysz
While drug therapies developed in the last 80 years have markedly
improved treatment outcomes and the management of some types of cancers,
the lack of effectiveness and side effects associated with the most
common treatment types remain unacceptable. However, recent
technological advances are leading to improved therapies based on
targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is
a comprehensive survey of all families of anticancer agents and
therapeutic approaches currently in use or in advanced stages of
clinical trials, including biological-based therapies.
The
book is unique in providing molecular structures for all anticancer
agents, discussing them in terms of history of development, chemistry,
mechanism of action, structure–function relationships, and pharmacology.
It also provides relevant information on side effects, dosing, and
formulation. The authors, renowned scientists in cancer research and
drug discovery, also provide up-to-date information on the drug
discovery process, including discussions of new research tools,
tumor-targeting strategies, and fundamental concepts in the relatively
new areas of precision medicine and chemoprevention.
Chemistry and Pharmacology of Anticancer Drugs is
an indispensable resource for cancer researchers, medicinal chemists
and other biomedical scientists involved in the development of new
anticancer therapies. Its breadth of coverage, clear explanations, and
illustrations also make it suitable for undergraduate and postgraduate
courses in medicine, pharmacy, nursing, dentistry, nutrition, the
biomedical sciences, and related disciplines.
Key Features:
- Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery
- Brings
together a broad spectrum of information relating to the chemistry and
pharmacology of all families of anticancer agents and therapies
- Includes
up-to-date information on cutting-edge aspects of cancer treatments
such as biomarkers, pharmacogenetics, and pharmacogenomics
- Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"
