| Author(s) | T. Shantha Raju |
| Year | 2019
|
| Pages | 297 |
| Language | English |
| Format | PDF |
| Size | 5 MB
|
| Publisher | Wiley |
| ISBN | 1119053315, 978-1119053316 |
A Comprehensive Guide to Crucial Attributes of Therapeutic Proteins in Biological Pharmaceuticals
With
this book, Dr. Raju offers a valuable resource for professionals
involved in research and development of biopharmaceutical and biosimilar
drugs. This is a highly relevant work, as medical practitioners have
increasingly turned to biopharmaceutical medicines in their search for
safe and reliable treatments for complex diseases, while pharmaceutical
researchers seek to expand the availability of biopharmaceuticals and
create more affordable biosimilar alternatives.
Readers receive a
thorough overview of the major co-translational modifications (CTMs)
and post-translational modifications (PTMs) of therapeutic proteins
relevant to the development of biotherapeutics. The majority of chapters
detail individual CTMs and PTMs that may affect the physicochemical,
biochemical, biological, pharmacokinetic, immunological, toxicological
etc. properties of proteins. In addition, readers are guided on the
methodology necessary to analyze and characterize these modifications.
Thus, readers gain not only an understanding of CTMs/PTMs, but also the
ability to design and assess their own structure-function studies for
experimental molecules. Specific features and topics include:
- Discussion of the research behind and expansion of biopharmaceuticals
- Twenty
chapters detailing relevant CTMs and PTMs of proteins, such as
glycosylation, oxidation, phosphorylation, methylation, proteolysis,
etc.
- Each chapter offers an introduction and guide to the
mechanisms and biological significance of an individual CTM or PTM,
including practical guidance for experiment design and analysis
- An
appendix of biologic pharmaceuticals currently on the market, along
with an assessment of their PTMs and overall safety and efficacy
This
volume will prove a key reference on the shelves of industry and
academic researchers involved in the study and development of
biochemistry, molecular biology, biopharmaceuticals and proteins in
medicine, particularly as biopharmaceuticals and biosimilars become ever
more prominent tools in the field of healthcare.
