1st Edition
by Andrea Trabocchi (Author), Stuart L. Schreiber (Foreword)
Discover an enhanced synthetic approach to developing and screening chemical compound libraries
Diversity-oriented
synthesis is a new paradigm for developing large collections of
structurally diverse small molecules as probes to investigate biological
pathways. This book presents the most effective methods in
diversity-oriented synthesis for creating small molecule collections. It
offers tested and proven strategies for developing diversity-oriented
synthetic libraries and screening methods for identifying ligands.
Lastly, it explores some promising new applications based on
diversity-oriented synthesis that have the potential to dramatically
advance studies in drug discovery and chemical biology.
Diversity-Oriented Synthesis
begins with an introductory chapter that explores the basics, including
a discussion of the relationship between diversity-oriented synthesis
and classic combinatorial chemistry. Divided into four parts, the book:
- Offers
key chemical methods for the generation of small molecules using
diversity-oriented principles, including peptidomimetics and macrocycles
- Expands on the concept of diversity-oriented synthesis by describing chemical libraries
- Provides
modern approaches to screening diversity-oriented synthetic libraries,
including high-throughput and high-content screening, small molecule
microarrays, and smart screening assays
- Presents the
applications of diversity-oriented synthetic libraries and small
molecules in drug discovery and chemical biology, reporting the results
of key studies and forecasting the role of diversity-oriented synthesis
in future biomedical research
This book has been written
and edited by leading international experts in organic synthesis and its
applications. Their contributions are based on a thorough review of the
current literature as well as their own firsthand experience developing
synthetic methods and applications.
Clearly written and extensively referenced, Diversity-Oriented Synthesis
introduces novices to this highly promising field of research and
serves as a springboard for experts to advance their own research
studies and develop new applications.
