1st Edition
by Prof. Jan Hermans (Author), Barry Lentz (Author)
Progressively builds a deep understanding of macromolecular behavior
Based
on each of the authors' roughly forty years of biophysics research and
teaching experience, this text instills readers with a deep
understanding of the biophysics of macromolecules. It sets a solid
foundation in the basics by beginning with core physical concepts such
as thermodynamics, quantum chemical models, molecular structure and
interactions, and water and the hydrophobic effect. Next, the book
examines statistical mechanics, protein-ligand binding, and
conformational stability. Finally, the authors address kinetics and
equilibria, exploring underlying theory, protein folding, and stochastic
models.
With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules. The text features coverage of:
- Basic theory, applications, and new research findings
- Related topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulations
- Principles and applications of molecular simulations in a dedicated chapter and interspersed throughout the text
- Macromolecular binding equilibria from the perspective of statistical mechanics
- Stochastic processes related to macromolecules
Suggested
readings at the end of each chapter include original research papers,
reviews and monographs, enabling readers to explore individual topics in
greater depth. At the end of the text, ten appendices offer refreshers
on mathematical treatments, including probability, computational
methods, Poisson equations, and defining molecular boundaries.
With its classroom-tested pedagogical approach, Equilibria and Kinetics of Biological Macromolecules
is recommended as a graduate-level textbook for biophysics courses and
as a reference for researchers who want to strengthen their
understanding of macromolecular behavior.
