1st ed. 2020 Edition
by Whitney B. Pope (Editor)
This book covers physiologic, metabolic and molecular imaging for
gliomas. Gliomas are the most common primary brain tumors. Imaging is
critical for glioma management because of its ability to noninvasively
define the anatomic location and extent of disease. While conventional
MRI is used to guide current treatments, multiple studies suggest
molecular features of gliomas may be identified with noninvasive
imaging, including physiologic MRI and amino acid positron emission
tomography (PET). These advanced imaging techniques have the promise to
help elucidate underlying tumor biology and provide important
information that could be integrated into routine clinical practice.
The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn:
- current standard
imaging methodologies used in clinical practice for patients undergoing
treatment for glioma and the implications of emerging treatment
modalities including immunotherapy
- the theoretical basis for
advanced imaging techniques including diffusion and perfusion MRI, MR
spectroscopy, CEST and amino acid PET
- the relationship between
imaging and molecular/genomic glioma features incorporated in the WHO
2016 classification update and the potential application of machine
learning
- about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials
- of
the gaps in knowledge that impede optimal patient management and the
cutting edge imaging techniques that could address these deficits
