1st Edition
by Jerold Chun (Author), Timothy Hla (Co-editor), Sarah Spiegel (Co-editor), Wouter Moolenaar (Co-editor)
The current state of the science supporting new research in lysophospholipids
The
study of lysophospholipids exploded with the discovery of cell surface
receptors on both lysophosphatidic acid (LPA) and sphingosine
1-phosphate (S1P). Since then, thousands of original research
reports―ranging from fundamental cell signaling to the physiology and
pathophysiology of individual organ systems―have centered on
lysophospholipids. This book draws together and analyzes the current
literature to provide readers with a state-of-the-science review as well
as current techniques that support research in all aspects of the field
of lysophospholipid signaling.
Lysophospholipid Receptors is divided into three sections:
- Receptors and other possible effectors
- Enzymes
- Physiology and pathophysiology
Within
each section, the authors explain the similarities and differences
between LPA and S1P signaling. Examples are provided that demonstrate
the underlying mechanisms of lysophospholipid signaling across a broad
range of organ systems, such as S1P signaling in cardiovascular
physiology and disease and the neural effects of LPA signaling.
Extensive references at the end of each chapter provide a gateway to the
literature and facilitate further research into individual topics.
Each
chapter has been authored by one or more leading international
authorities in lysophospholipid research. Based on a thorough analysis
of the current research, the authors set forth what is established
science and offer their expert opinion and perspective on new and
emerging areas of research, setting the stage for further investigations
that will solve current problems in the field.
