2nd Edition
by Robert Crichton (Author), Roberta Ward (Author)
Neurodegenerative diseases of the
human brain appear in various forms, resulting in disorders of movement
and coordination, cognitive deterioration and psychiatric disturbances.
Many of the key factors leading to neurodegenerative diseases are
similar, including the dysfunction of metal ion homeostasis,
redox-active metal ions generating oxidative stress, and intracellular
inclusion bodies.
Metal-based Neurodegeneration presents a
detailed survey of the molecular origins of neurodegenerative diseases.
Each chapter is dedicated to a specific disease, presenting the latest
scientific findings, including details of their biochemical actors
(proteins or peptides), their normal and pathological conformations, and
a description of the diseases characteristics, with an emphasis on the
role of metal-induced oxidative stress, which can result in the
production of intracellular aggregates of target proteins and peptides.
Topics covered include:
- Brain function, physiology and the blood-brain barrier
- Immune system and neuroinflammation
- Aging and mild cognitive impairment, MCI
- Parkinson’s Disease
- Alzheimer’s Disease
- Creutzfelt-Jakob and related prion diseases
- Alcoholic Brain Damage
- Therapeutic strategies to combat the onset and progression of neurological diseases
This extensively updated, full colour, second edition of Metal-based Neurodegeneration
is an essential text for research scientists and clinicians working in
gerontology, neuropathology, neurochemistry, and metalloprotein
mechanisms.
