(Wiley Series in Protein and Peptide Science) 1st Edition
by Eugene Permyakov (Author)
Synthesizes the current knowledge in the field and provides new insights into medical applications
Metalloproteomics
is the large-scale study of metal-binding proteins. These proteins,
which represent about one quarter of all the proteins in the Protein
Data Bank, play important roles in all biological systems and all
biological processes. Metalloproteomics provides the latest
information on all major families of metal-binding proteins, including
their structural, physico-chemical, and functional properties, enabling
readers to better understand these proteins. Moreover, the book
demonstrates how understanding the structures, properties, and functions
of intracellular and extracellular metal-binding proteins may unlock
the key to drug development for the treatment of a myriad of diseases.
Written
by Eugene Permyakov, an international expert and pioneer in the
structural analysis of metal-binding proteins, the book offers
- Theoretical introduction to cation binding
-
Broad range of methods for investigating the binding of different cations to proteins
-
Characteristics
of interactions of physiologically important cations of Ca, Mg, Zn, Fe,
Mn, Co, Cu, Ni, Mo, W, Na, and K with proteins
-
Detailed considerations of structural and physico-chemical properties of the metal-binding proteins
-
Interactions of all other metal cations with proteins
-
Interactions of different types of cations with nucleic acids
Throughout
the text, the author integrates principles of proteomics. In addition,
detailed examples underscore the role metal-binding proteins play in
health and medicine.
Bringing together and analyzing all the latest findings, Metalloproteomics'
scope and level of insight are unparalleled. It is recommended for
biophysicists, biochemists, enzymologists, cell and molecular
biologists, protein and peptide scientists, organic and bioinorganic
chemists, and chemical biologists.
