1st ed. 2020 Edition
by Shan-Ho Chou (Editor), Nicolas Guiliani (Editor), Vincent T. Lee (Editor), Ute Römling (Editor)
This book explores the broad and diverse biological and physiological
impacts of established and newly discovered cyclic di-nucleotide second
messenger signaling systems, while also providing descriptions of the
intriguing biochemical characteristics of multiple turnover enzymes and
receptors. The respective chapters discuss the commonalities and
diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic
GMP-AMP signaling systems in manifold Gram-negative and Gram-positive
bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described.
In
turn, the various aspects of bacterial physiology affected by these
signaling systems– e.g. biofilm formation and dispersal, the cell cycle,
motility, virulence, production of antimicrobials, fundamental
metabolism and osmohomeostasis – are discussed in detail in the context
of different microorganisms. Dedicated chapters focus on the population
diversity of cyclic dinucleotide signaling systems, their tendency to be
horizontally transferred, the cyclic di-GMP signaling system in the
social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and
the development of strategies for interfering with cyclic dinucleotide
signaling in order to manipulate microbial behavior.
Taken
together, the chapters provide an authoritative source of information
for a broad readership: beginners and advanced researchers from various
disciplines; individuals seeking a broad overview of cyclic
di-nucleotide signaling; and those who want to learn more about specific
aspects. Also featuring reviews with a forward-looking perspective, the
book offers a valuable source of inspiration for future research
directions.
