(Current Cancer Research) 1st ed. 2019 Edition
by Erle S. Robertson (Editor)
This book ventures into a new and exciting area of discovery that
directly ties our current knowledge of cancer to the discovery of
microorganisms associated with different types of cancers. Recent
studies demonstrate that microorganisms are directly linked to the
establishment of cancers and that they can also contribute to the
initiation, as well as persistence of, the cancers. Microbiome and Cancer
covers the current knowledge of microbiome and its association with
human cancers. It provides important reading for novices, senior
undergraduates in cancer and microbiology, graduate students, junior
investigators, residents, fellows and established investigators in the
fields of cancer and microbiology. We cover areas related to known,
broad concepts in microbiology and how they can relate to the ongoing
discoveries of the micro-environment and the changes in the metabolic
and physiologic states in that micro-environment, which are important
for the ongoing nurturing and survival of the poly-microbial content
that dictates activities in that micro-environment.
We cover the
interactions of microorganisms associated with gastric carcinomas, which
are important for driving this particular cancer. Additional areas
include oral cancers, skin cancers, ovarian cancers, breast cancers,
nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin’s and
non-Hodgkin’s lymphomas, glioblastoma multiforme, hepatocellular
carcinomas, as well as the inflammatory response related to the
infectious agents in cancers. This book covers the metabolic changes
that occur because of infection and their support for development of
cancers, chronic infection and development of therapeutic strategies for
detection and control of the infection.
The field of
microbiome research has exploded over the last five years, and we are
now understanding more and more about the context in which
microorganisms can contribute to the onset of cancers in humans. The
field of microbiome research has demonstrated that the human body has
specific biomes for tissues and that changes in these biomes at the
specific organ sites can result in disease. These changes can result in
dramatic differences in metabolic shifts that, together with genetic
mutations, will produce the perfect niche for establishment of the
particular infection programmes in that organ site. We are just
beginning to understand what those changes are and how they influence
the disease state. Overall, we hope to bring together the varying
degrees of fluctuations in the microbiome at the major organ sites and
how these changes affect the normal cellular processes because of
dysregulation, leading to proliferation of the associated tissues.
