1st Edition
by Saura C. Sahu (Author)
During the past decade it has
become evident that microRNAs regulate gene expressions and control many
developmental and cellular processes in eukaryotic organisms. Recent
studies suggest that microRNAs play an important role in toxicogenomics
and are likely to play an important role in a range of human diseases
including cancer.
microRNAs in Toxicology and Medicine is
a comprehensive and authoritative compilation of up-to-date
developments in this emerging research area, presented by
internationally recognized investigators. It focuses on the role of
microRNA in biology and medicine with a special emphasis on toxicology.
Divided into six parts, topics covered include:
- microRNA
and toxicology – including environmental toxicants and perturbation of
miRNA signaling; microRNA, and Disease States featuring microRNAs in
drug-induced liver toxicity, microRNAs and Inflammation the regulatory
role of microRNA in mutagenesis, microRNAs and cancer, and the role of
microRNAs in tumor progression and therapy, as well as current
understanding of microRNAs as therapeutic targets in cancer
- microRNAs and disease states
- microRNAs and stem cells
- microRNAs and genomics
- microRNAs and epigenomics
- microRNAs
and biomarkers – including body fluid microRNAs as toxicological
biomarkers, cell-free microRNAs as biomarkers in human diseases, and
circulating microRNAs as biomarkers of drug-induced pancreatitis
microRNAs in Toxicology and Medicine
is an essential insight into the current trends and future directions
of research in this rapidly expanding field for investigators,
toxicologists, risk assessors, and regulators in academia, medical
settings, industry, and government.
