1st Edition
by Efstratios N. Pistikopoulos (Editor), Ioana Nascu (Editor), Eirini G. Velliou (Editor)
Shows the newest developments
in the field of multi-parametric model predictive control and
optimization and their application for drug delivery systems
This
book is based on the Modelling, Control and Optimization of Biomedical
Systems (MOBILE) project, which was created to derive intelligent
computer model-based systems for optimization of biomedical drug
delivery systems in the cases of diabetes, anaesthesia, and blood
cancer. These systems can ensure reliable and fast calculation of the
optimal drug dosage without the need for an online computer―while taking
into account the specifics and constraints of the patient model,
flexibility to adapt to changing patient characteristics and
incorporation of the physician’s performance criteria, and maintaining
the safety of the patients.
Modelling Optimization and Control of Biomedical Systems covers:
mathematical modelling of drug delivery systems; model analysis,
parameter estimation, and approximation; optimization and control;
sensitivity analysis & model reduction; multi-parametric programming
and model predictive control; estimation techniques;
physiologically-based patient model; control design for volatile
anaesthesia; multiparametric model based approach to intravenous
anaesthesia; hybrid model predictive control strategies; Type I Diabetes
Mellitus; in vitro and in silico block of the integrated platform for
the study of leukaemia; chemotherapy treatment as a process systems
application; and more.
- Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project
- Presents
in detail the theoretical background, computational tools, and methods
that are used in all the different biomedical systems
- Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia
- Provides an overview of the framework for modelling, optimization, and control of biomedical systems
This
book will appeal to students, researchers, and scientists working on
the modelling, control, and optimization of biomedical systems and to
those involved in cancer treatment, anaesthsia, and drug delivery
systems.
