1st ed. 2019 Edition
by Dayong Wang (Author)
This book introduces readers to intestinal and epidermal barriers,
and to toxicity induction of environmental toxicants or stresses in the
intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans.
In addition, it discusses the protective responses of various organs
and nematodes’ avoidance behaviour with regard to environmental
toxicants or stresses. The intestinal, epidermal, neuronal, and germline
signalling pathways required for the regulation of toxicity of
environmental toxicants or stresses are also introduced and discussed.
As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans
has been successfully and widely used in both toxicity assessments and
toxicological studies on various environmental toxicants and stresses.
Once exposure to certain environmental toxicants has occurred, the
toxicants can enter into the primary targeted organs (such as intestinal
cells), and even be translocated into secondary targeted organs (such
as reproductive organs and neurons). Based on related available data,
this book provides a systematic understanding of target organ toxicology
in C. elegans.
