English | 2023 | PDF | 3 MB | 392 Pages
Moyra Smith, B0BYD5FN4P, 0443153523, 0443153531, 9780443153532, 978-0443153532, 9780443153525, 978-0443153525, 978-0-443-15352-5
The Regulatory Genome in Adaptation,
Evolution, Development, and Disease synthesizes insights from recent
genomic and gene expression studies across organisms, from humans to
plants, animals, and single cell life, exploring common roles gene
regulation plays in adaptive evolution, developmental biology and
susceptibility to disease. The book sheds light on gene regulation
across evolutionary timelines, illuminating new areas of focus and
future research. Chapters consider key elements in gene expression
regulation, fundamentals of genomic alterations over time, and in
response to environmental and local conditions, epigenetics in adaptive
evolution, and adaptive gene regulation in healthy processes and
developmental biology, and in disease biology.
Throughout
the book, a comparative approach is adopted across organisms to
highlight common evolutionary themes and genome diversity revealed by
recent sequencing and GWAS studies, as well as how this informs our
understanding of human adaptive evolution. The book finishes by
detailing how we can use this knowledge to impact disease outcomes and
healthy human metabolism, development, and physiology.
- Reviews key elements in the regulation of gene expression and modes of studying gene regulation across evolutionary timelines
-
Adopts a cross-species view, synthesizing recent sequencing and GWAS
studies across organisms to draw out fresh meaning and highlight
pathways for future research
- Considers altered gene expression
associated with developmental defects and disease, as well as healthy
biology and physiology, and our adaptive response to disease influence
