1st ed. 2020 Edition
by Jeffrey Y. C. Wong (Editor), Susanta K. Hui (Editor)
This book, written by a team of international experts, concisely
reviews the rationale and clinical application of image-guided total
marrow irradiation, a rapidly emerging area in radiation oncology and
hematopoietic cell transplantation. The aim is to provide the practicing
radiation oncologist, hematologist, medical physicist, and bone marrow
transplant researcher with a fundamental understanding of key aspects
and an appreciation of the increasing significance of total marrow
irradiation as conditioning for bone marrow transplantation. Detailed
attention is paid to the impacts of recent advances in radiation therapy
technology, functional PET and MRI, and understanding of the response
of bone marrow to radiation. Full consideration is also given to the
ways in which technological advances in image-guided radiation therapy
have created new opportunities to treat bone marrow transplant patients
with limited transplant options due to advanced disease, age, or
co-morbidities. Further topics covered include the ways in which cancer
stem cells and the marrow microenvironment influence response to
radiation therapy and the implementation of new-generation predictive
radiobiologic factors in the clinic.
