2nd Edition
by Alex Avdeef (Author)
Explains how to perform and analyze the results of the latest physicochemical methods
With
this book as their guide, readers have access to all the current
information needed to thoroughly investigate and accurately determine a
compound's pharmaceutical properties and their effects on drug
absorption. The book emphasizes oral absorption, explaining all the
physicochemical methods used today to analyze drug candidates. Moreover,
the author provides expert guidance to help readers analyze the results
of their studies in order to select the most promising drug candidates.
This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:
- Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group
- Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier
- Expanded information and methods to support pKa determination
- New examples explaining the treatment of practically insoluble test compounds
- Additional case studies demonstrating the use of the latest physicochemical techniques
- New, revised, and expanded database tables throughout the book
Well
over 200 drawings help readers better understand difficult concepts and
provide a visual guide to complex procedures. In addition, over 800
references serve as a gateway to the primary literature in the field,
facilitating further research into all the topics covered in the book.
This Second Edition
is recommended as a reference for researchers in pharmaceutical R&D
as well as in agrochemical, environmental, and other related areas of
research. It is also recommended as a supplemental text for graduate
courses in pharmaceutics.
