1st Edition
by Walter A. Korfmacher (Editor)
Facilitates the discovery and development of new, effective therapeutics
With
coverage of the latest mass spectrometry technology, this book explains
how mass spectrometry can be used to enhance almost all phases of drug
discovery and drug development, including new and emerging applications.
The book's fifteen chapters have been written by leading pharmaceutical
and analytical scientists. Their contributions are based on a thorough
review of the current literature as well as their own experience
developing new mass spectrometry techniques to improve the ability to
discover and develop new and effective therapeutics.
Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers:
- HPLC–high-resolution mass spectrometry for quantitative assays
- Mass spectrometry for siRNA
- Quantitative analysis of peptides
- Mass spectrometry analysis of biological drugs
- Applications that support medicinal chemistry investigations
- Mass spectrometry imaging and profiling
Throughout
the book, detailed examples underscore the growing role of mass
spectrometry throughout the drug discovery and development process. In
addition, images of mass spectra are provided to explain how results are
interpreted. Extensive references at the end of each chapter guide
readers to the primary literature in the field.
Mass Spectrometry for Drug Discovery and Drug Development
is recommended for readers in pharmaceutics, including medicinal
chemists, analytical chemists, and drug metabolism scientists. All
readers will discover how mass spectrometry can streamline and advance
new drug discovery and development efforts.
