(Oxidative Stress and Disease) 1st Edition
by André Kleinridders (Editor)
The
brain is crucial for the regulation of whole-body metabolism and
behavior. The pancreas-derived hormone insulin modulates brain function
and affects energy metabolism as well as cognition. This is partially
achieved by modulating several types of brain cell populations including
those relevant to satiety and reward. Importantly, brains of
Alzheimer´s disease patients exhibit a signature of brain insulin
resistance with perturbed brain metabolism. This book will cover the
basics of insulin signaling in the brain and will describe concepts of
insulin resistance, a feature of type 2 diabetes. Moreover insulin´s
effect on cognitive function will be pointed out and the association
between brain insulin resistance and neurodegenerative diseases
discussed. Additionally, potential behavioral and pharmacological
concepts which can affect brain insulin signaling will be summarized.
Key Features:
- Summarizes insulin and the closely related IGF-1 receptor signaling
- Depicts concepts of insulin resistance
- Highlights the importance of conserved brain insulin signaling for brain function, metabolism, and behavior
- Describes potential behavioral and pharmacological approaches to support brain insulin signaling
