English | 2023 | PDF | 28 MB | 773 Pages
Wen-Quan Zou, Pierluigi Gambetti, B0BRGVJ3L2, 3031205650, 3031205642, 3031205677, 9783031205675, 9783031205644, 9783031205651, 978-3031205675, 978-3031205644, 978-3031205651
Transmissible spongiform
encephalopathies (TSE), known as prion diseases, have been recognized
for nearly 300 years in animals and almost 100 years in humans. Modern
studies, including the protein-misfolding cyclic amplification (PMCA),
have greatly advanced our understanding of the pathogenesis of prion
diseases and facilitated the identification of new prion diseases in
animals and humans. In the second edition of Prions and Diseases, more
than 60 leading researchers and clinicians worldwide provide an
up-to-date discussion of these unique infectious pathogens and their
associated diseases. The book provides up-to-date knowledge about the
etiology, pathogenesis, classification, histopathological, and clinical
aspects of the full range of animal and human prion diseases. As a
result, the book contains by far the most authoritative views about the
past, present, and future of prions and prion diseases. The new second
edition covers such important emerging topics such as inherited human
prion disease, stem-cell models in prion research, human prion disease
surveillance, and gene therapy strategies.
