Prions and Diseases 2nd Edition

English | 2023 | PDF | 28 MB | 773 Pages

Wen-Quan Zou, Pierluigi Gambetti, B0BRGVJ3L2, 3031205650, 3031205642, 3031205677, 9783031205675, 9783031205644, 9783031205651, 978-3031205675, 978-3031205644, 978-3031205651

Transmissible spongiform encephalopathies (TSE), known as prion  diseases, have been recognized for nearly 300 years in animals and  almost 100 years in humans. Modern studies, including the  protein-misfolding cyclic amplification (PMCA), have greatly advanced  our understanding of the pathogenesis of prion diseases and facilitated  the identification of new prion diseases in animals and humans. In the  second edition of Prions and Diseases, more than 60 leading researchers  and clinicians worldwide provide an up-to-date discussion of these  unique infectious pathogens and their associated diseases. The book  provides up-to-date knowledge about the etiology, pathogenesis,  classification, histopathological, and clinical aspects of the full  range of animal and human prion diseases. As a result, the book contains  by far the most authoritative views about the past, present, and future  of prions and prion diseases. The new second edition covers such  important emerging topics such as inherited human prion disease,  stem-cell models in prion research, human prion disease surveillance,  and gene therapy strategies.